Sinopsis
Han pasado dos años desde que el tranquilo Peter Parker dejó a Mary Jane Watson, su gran amor, y decidió seguir asumir sus responsabilidades como Spider-Man. Peter debe afrontar nuevos desafíos mientras lucha contra el don y la maldición de sus poderes equilibrando sus dos identidades: el escurridizo superhéroe Spider-Man y el estudiante universitario. Las relaciones con las personas que más aprecia están ahora en peligro de ser descubiertas con la aparición del poderoso villano de múltiples tentáculos Doctor Octopus, "Doc Ock". Su atracción por M.J. se hace más fuerte mientras lucha contra el impulso de abandonar su vida secreta y declarar su amor. Mientras tanto, M.J. ha seguido con su vida. Se ha embarcado en su carrera de actriz y tiene un nuevo hombre en su vida. La relación de Peter con su mejor amigo Harry Osborn se ha alejado por la creciente venganza de Harry contra Spider-Man, al que considera responsable de la muerte de su padre.
Reparto
Tobey Maguire — Spider-Man / Peter ParkerKirsten Dunst — Mary Jane WatsonJames Franco — Harry OsbornAlfred Molina — Doc Ock / Otto OctaviusRosemary Harris — May ParkerJ.K. Simmons — J. Jonah JamesonDonna Murphy — Rosalie OctaviusDaniel Gillies — John JamesonDylan Baker — Dr. Curt ConnorsBill Nunn — Joseph 'Robbie' RobertsonVanessa Ferlito — LouiseAasif Mandvi — Mr. AzizWillem Dafoe — Green Goblin / Norman OsbornCliff Robertson — Ben ParkerTed Raimi — HoffmanElizabeth Banks — Miss BrantBruce Campbell — Snooty UsherGregg Edelman — Dr. DavisIlya Baskin — Mr. DitkovitchMageina Tovah — UrsulaDaniel Dae Kim — RaymondHal Sparks — Elevator PassengerJoel McHale — Mr. JacksStan Lee — Man Dodging DebrisKelly Connell — Dr. IsaacsBrent Briscoe — Garbage ManEmily Deschanel — ReceptionistJason Fiore-Ortiz — Henry JacksonScott Spiegel — Man on BalconyAndy Bale — OsCorp ExecutiveChristine Estabrook — Mrs. JamesonMolly Cheek — Society WomanJohn Paxton — HousemanJoy Bryant — Woman at WebJoanne Baron — Skeptical ScientistPeter McRobbie — OsCorp RepresentativeTimothy Jerome — Injured ScientistTaylor Gilbert — Mrs. WatsonPeter Vouras — Stage ManagerDonnell Rawlings — Pizza "Heist" WitnessZachry Rogers — Boy saved by Spider-ManElla Rogers — Girl saved by Spider-ManLouis Lombardi — Poker PlayerMarc John Jefferies — Amazed KidRoshon Fegan — Amazed KidBrendan Patrick Connor — Theater Traffic CopReed Diamond — 'Algernon'Dan Callahan — 'Jack'Elyse Dinh — ViolinistJohn Landis — DoctorTim Storms — Chainsaw DoctorSusie Park — Clawing NursePatricia M. Peters — Screaming NurseMichael Edward Thomas — Man at FireAnne Betancourt — Woman at FireVenus Lam — Child in Burning BuildingBill E. Rogers — FiremanJoe Virzi — FiremanTom Carey — Train ConductorJopaul Van Epp — Boy with MaskWeston Epp — Boy with MaskPeter Allas — Train PassengerBrianna Brown — Train PassengerBill Calvert — Train PassengerTony Campisi — Train PassengerJoey Diaz — Train PassengerChloe Dykstra — Train PassengerSimone Gordon — Train PassengerDan Hicks — Train PassengerJulia Max — Train PassengerSavannah Pope — Train PassengerTimothy Patrick Quill — Train PassengerJill Sayre — Train PassengerRickey G. Williams — Train PassengerMichael Arthur — NYPD Officer (uncredited)Frank Bonsangue — Pizza Man (uncredited)Cindy Cheung — Chinese Daughter (uncredited)Phil LaMarr — Train Passenger (uncredited)Andre M. Johnson — Fireman 2 (uncredited)Peter Cincotti — Piano Player in Planetarium (uncredited)Peyton List — Little Girl Playing on Steps (uncredited)Spencer List — Little Boy Playing on Steps (uncredited)Troy Metcalf — Blue Collar Guy (uncredited)Scott Ross — Pedestrian (uncredited)Bonnie Somerville — Screaming Woman (uncredited)Wesley Volcy — Columbia University Student (uncredited)Lou Volpe — Man at Web (uncredited)Garrett Warren — Bearded Doctor (uncredited)Joseph M. Caracciolo — Priest at Mary Jane's Wedding (uncredited)David Boston — Pedestrian (uncredited)Sho Brown — Passenger (uncredited)Sal Ardisi — Parent (uncredited)Edward Johnson — Planetarium (uncredited)Grant Curtis — Hot Dog Vendor (uncredited)Vince Cupone — Victim (uncredited)William E. Corcoran — Stock Broker (uncredited)Mohammed Hassan — Middle Eastern Taxi Driver (uncredited)Rachel Lehrer — Hot Girl (uncredited)Gene LeBell — Train Passenger (uncredited)Lorelei Llee — Bank Employee (uncredited)Joseph Nelson — Extra (uncredited)Claudia Katz Minnick — Robbie's Assistant (uncredited)Ronn Ozuk — Cop (uncredited)Denney Pierce — Train Passenger (uncredited)Carla Rhodes — Phone Booth Girl (uncredited)Randy Reinholz — Train Passenger (uncredited)Rachelle Roderick — Jane, Engineer (uncredited)Angel Katherine Taormina — Female Onlooker on Street (uncredited)Douglas Swander — Train Passenger (uncredited)Jimmy Star — Reporter (uncredited)Jack Wetherall — Train Passenger (uncredited)Ken Wharton — Uptight Businessman (uncredited)Henry Truong — Doc Ock Lab Assistant #2 (uncredited)Al Collado — Cab Driver (uncredited)Lee Cogburn — Train Passenger (uncredited)Sam Raimi — University Student with Bag (uncredited)John Cameron — Man Buying 'Spider-Man No More' Newspaper (uncredited)